A large and destructive tornado has touched down in Tupelo, Mississippi

Emergency crews are assessing damage in Tupelo after a large and destructive tornado touched down Sunday night.

The National Weather Service in Memphis posted a series of tweets warning people to take shelter as the damaging tornado tore through the city.

The mayor’s office warned residents to stay home following the tornado so crews can assess damage.

“Please do not get out and drive. It is dangerous — there are reports that power lines are down in the roads,” a post on the Tupelo Mayor’s Office Facebook page said. “Prayers that all are safe, and please keep our crews and first responders in your prayers also.”

Active tornado warnings were in place Sunday night for Mississippi, NOAA Weather-Ready Nation Ambassadors said on Twitter.

The town of Calhoun City, about 50 miles southwest of Tupelo, was also impacted by a tornado in the same line of storms, Sheriff Greg Pollan wrote in a post on Calhoun County MS Sheriff Facebook page.

“The town of Calhoun City was hit hard tonight. Light poles have been snapped off. Trees in a few homes. Trees on vehicles. Damage to several businesses. Fortunately we have had no reports at this time of injuries,” the post said. “We are asking that you PLEASE STAY OFF THE ROADS AT THIS TIME. Emergency personnel are working feverishly to open the roads as quickly as possible.”

Earlier Sunday, another damaging tornado touched down in Yazoo City, about 170 miles southwest of Tupelo, as part of a round of storms sweeping across the Southeast.

“We do not have any injuries reported but have numerous damaged structures,” Yazoo County Emergency Management Director Jack Willingham told CNN in an email.

This is a developing story and will be updated as more information comes available.